Similarly, the protein level of CDK4 was higher in tumor tissues than in nomal or paired paracancerous issues (Figure 4b), and its expression level of CDK4 was closely associated with the cancer stage (Figure 4c): Compared with the normal group,the later the tumor stage, the higher the expression level(due to too few cases in the stage4, there is no statistical difference. The gene discussed is CDK4; the disease is neoplasm.