Based on prognostic analysis including overall survival and disease-free survival of the 14 DEGs that were screened through the GEPIA online website (Figure 2, Figure 3) and results (Figure 2b), we found that only CDK4 and PSMD14 showed significant statistical difference(all P values are less than 0.05) in both disease-free survival and overall survival of patients, whereas PSMD14 has been reported to be related to the proliferation and metastasis of hepatocellular carcinoma cells [13].Thus, the hub gene CDK4 is regarded as an important candidate gene for research. Here, CDK4 is linked to hepatocellular carcinoma.