In this study, CDK4 expression in HCC tissues exceeded that in non-tumor tissues,and it showed the huge potential of being a tumor marker for predicting patients’ prognosis.Moreover, our findings indicated that CDK4 enhances tumor migration and invasion by modulating EMT via the Wnt/β-catenin pathway.All these findings highlighted CDK4 as an independent prognostic factor and a potential target for the treatment of hepatocellular carcinoma metastasis. This evidence concerns the gene CDK4 and neoplasm.