CD4 and neoplasm: ESR1(Figure 4j) expression level was negatively associated with tumor purity (r= – 0.141, P= 1.88e−02), B cells (r = 0.141, P= 1.81e−02), CD4 + T cells (r = 0.185, P= 2.03e−03), and macrophages (r = 0.143, P = 1.76e−02).