IGHE and Autoimmunity: As a result, the autoimmunity of IgE and anti‐IgE antibodies caused the anti‐IgE antibody level in the SLE patient group to be significantly lower than that of the healthy control group, while the autoimmune result of FcεRIα and anti‐FcεRI antibody triggers tissue inflammatory damage caused by mast cell activation, which is worthy of further study and clarification.