Miescher et al.19reported that only when FcεRIα is not bound by IgE, anti‐FcεRI antibodies can bind to the cell surface FcεRIα, activate peripheral blood basophils, and cause inflammation. The results of this study also verified that there was no significant difference in serum IgE levels between the SLE group and the healthy control group. This evidence concerns the gene IGHE and systemic lupus erythematosus.