mTOR signaling has been demonstrated to be involved in the deposition of Aβ protein and the abnormal phosphorylation of tau protein in neurodegenerative diseases, and inhibition of mTOR by rapamycin ameliorated Aβ and tau pathology and the associated cognitive deficits by enhancing the autophagic removal of damaged or toxic proteins.48, 50, 51. The gene discussed is MAPT; the disease is Cognitive impairment.