The percentage of Ki67 cells present in the epithelia or cancer cells were quantified (n = 3 for each group) in control tissues with normal histology and in premalignant and invasive cancers tissues following DBPDE treatment demonstrating a significant increase in proliferation in premalignant lesions and invasive cancers (p<0.05) (Fig 2D). This evidence concerns the gene MKI67 and cancer.