The skew toward RBPs that decrease the amount of SERPINA1 long 3′UTR isoforms in individuals with COPD (Fig 5A and 5B) contradicts our observation of the 2.1-fold higher distal ratio (greater use of the distal site) in COPD lungs (Fig 2). The gene discussed is SERPINA1; the disease is chronic obstructive pulmonary disease.