Downregulated pathways in skeletal muscle of CKD patients included angiogenesis, Notch signaling, interferon-α response, interferon-γ response, and other inflammatory response pathways, while oxidative phosphorylation, Myc targets v1 and v2, reactive oxygen species, and fatty acid metabolism were upregulated (Figure 4G). This evidence concerns the gene TRGV9 and chronic kidney disease.