Downregulated pathways in skeletal muscle of CKD patients included angiogenesis, Notch signaling, interferon-α response, interferon-γ response, and other inflammatory response pathways, while oxidative phosphorylation, Myc targets v1 and v2, reactive oxygen species, and fatty acid metabolism were upregulated (Figure 4G). The gene discussed is MYC; the disease is chronic kidney disease.