CASP3 and neoplasm: As indicated in Figure 4, J–O, we found that knockdown of CPVL significantly suppressed tumor growth, as illustrated by decreased tumor growth rates, tumor weights, and Ki-67 and increased cleaved caspase 3 indexes from the shCPVL PDX mouse models compared with that of tumors from the control PDX mouse models (P < 0.05; Figure 4, J–O).