STAT1 and central nervous system cancer: The results reveal that the expression levels of STAT1 signaling pathway downstream response genes in glioma tissues were lower than those in matched adjacent noncancerous tissues and further decreased with advanced clinical grade and in the tumors with poor pathologic differentiation (Figure 5, G and H; Supplemental Figure 10, A–D; Supplemental Figure 11, A–D; and Supplemental Figure 12, A–D).