CPVL and central nervous system cancer: As CPVL was first characterized in human macrophages, we used the Single cell Glioma RNA-sequence database (TISCH, http://tisch.comp-genomics.org/) to validate that the macrophage cell in glioma is the major source of CPVL (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.146362DS1).