NFKB1 and colon carcinoma: We found that stable knockdown of GR in CT26.WT mouse colon carcinoma cells using shRNAs (Supplemental Figure 3A; see complete unedited blots in the supplemental material) significantly enhanced the LPS-mediated induction of several NF-κB target chemokine genes but not the tested cytokine genes (Supplemental Figure 3, B and C), suggesting that the accumulation of macrophages in the colons of GR iKO mice after DSS treatment (Figure 4, D and E) may be due to increased chemokines produced by GR-deficient colonic epithelium.