NR3C1 and colitis: Importantly, Flox and GR iKO mice exhibited comparable degrees of DSS-induced tissue damage after treatment with clodronate-containing liposomes (Figure 4, E and F, clodronate), indicating that intestinal epithelial GR deficiency–induced hypersensitivity to DSS-induced colitis is primarily mediated by enhanced macrophage recruitment to the colonic epithelium.