IL2RG and neoplasm: To test whether suppression of macrophage infiltration is involved in the BMZ-mediated increase of CT26.WT tumor growth, we repeated the BMZ-allograft procedure in NOD/SCID γ (NSG) mice, one of the most immunocompromised mouse strains that lacks mature T, B, and natural killer cells due to the scid mutation and Il2rg KO (35) but with functional macrophages (36, 37).