NR3C1 and colorectal cancer: To directly test this possibility, we treated Flox and GR iKO mice subjected to the AOM/DSS procedure with drinking water containing 2.5 μg/ml betamethasone (BMZ), a synthetic GC, from day 3 in the first DSS cycle (day 3) to 7 days into the first recovery phase (day 14) (Figure 6A, orange bar) and analyzed the effect of this treatment on DSS-induced inflammation and colorectal cancer formation at the end of the AOM/DSS procedure.