NR3C1 and colitis: However, the study by Muzzi et al. reported that GR iKO mice are hypersensitive to acute colitis–induced colorectal cancer formation in an acute AOM/DSS colorectal cancer model (18), which is in contrast with our observation that GR iKO mice are protected from colorectal cancer formation in a chronic inflammation–associated AOM/DSS colorectal cancer model.