ADGRE1 and colitis: Further immunohistochemical analysis revealed that the colons of GR-deficient mice had a greater accumulation of Emr1+ (also known as F4/80+) macrophages (Figure 4D) but not of total CD45+ immune cells nor CD3+ T cells (Supplemental Figure 2, D and E), suggesting that increased recruitment of macrophages may be accountable for the hypersensitivity of GR iKO mice to DSS-induced colitis.