To further assess the unexpected impact of intestinal epithelial GR deficiency on tissue recovery, we directly challenged Flox and GR iKO mice with an azoxymethane/DSS (AOM/DSS) chronic inflammation–associated colorectal cancer model, in which the mice were first injected with AOM to induce DNA damage and then treated with 3 cycles of alternating DSS-containing water and regular drinking water to induce chronic inflammation and repetitive tissue damage/repair (Figure 5B, top). The gene discussed is NR3C1; the disease is colorectal cancer.