DEFA6 and obesity due to melanocortin 4 receptor deficiency: The broadly tuned TAS2R agonist DB decreased DEFA6 mRNA expression in crypts of TAS2R43+ individuals by 43.4% ± 5.9 % (P < 0.001) and to a lesser extent in TAS2R43– individuals with obesity (26.7% ± 8.8%, P < 0.05; Figure 6J).