Previous studies already showed that the bitter-tasting compounds diclofenac (TAS2R14) and resveratrol (TAS2R14, TAS2R39) increased the NSAID-activated gene (NAG-1), which was later renamed GDF15, in a human colorectal carcinoma cell line (45, 46). The gene discussed is TAS2R39; the disease is colorectal carcinoma.