On the other hand, almost all the published results provided an unequivocal function of SORT1 SNPs in regulating lipid metabolism, shedding light on that the effect of 1p13.3 gene locus could be identified as a novel biomarker representing the risk of dyslipidemia and its related cardiometabolic syndrome, such as overweight/obesity, atherosclerotic coronary diseases, and diabetes mellitus. Here, SORT1 is linked to obesity due to melanocortin 4 receptor deficiency.