In this review, we put forward a summary of several research which has demonstrated that the characteristics of hypothyroidism-related dyslipidemia; moreover, it is also summarized that the hypothyroidism-related dyslipidemia is closely associated with the altered serum concentrations of thyroid hormones and thyroid-stimulating hormone, indicating that hypothyroidism could induce dyslipidemia and its related cardio-metabolic disorder diseases. This evidence concerns the gene TG and hypothyroidism.