ADIPOR1 and retinal degeneration: For instance, mutant of the AdipoR1 gene in retinal pigment epithelial cells results in the inability to take up and retain the essential fatty acid family member docosahexaenoic acid (DHA, 22:6,n-3), further leading to photoreceptor cell death and retinal degeneration (Rice et al., 2015; Sluch et al., 2018).