In breast cancer cells, lncRNA ANCR binds EZH2 and also promotes the binding of CDK1 kinase to EZH2, which increases the phosphorylation of threonine Thr-345 and Thr-487 in EZH2, ultimately leading to the ubiquitination of EZH2 [17,28]. Here, EZH2 is linked to breast carcinoma.