Collectively, through the analysis using Oncomine, GEPIA, UALCAN, and Kaplan–Meier Plotter databases, consistent results highlight the downregulation of ABR, PREX1, DOCK2, and DOCK4 in NSCLC, and they notably predict the poor prognosis of NSCLC patients. The gene discussed is DOCK2; the disease is non-small cell lung carcinoma.