Potential drugs against AKI and renal fibrosis are known as DPP-4 inhibitor linagliptin, empagliflozin, Sirtuin 3, JAK/STAT inhibitors, glycolysis inhibitors, angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, and peptide AcSDKP [15–21]. Here, SIRT3 is linked to acute kidney injury.