MAPT and Alzheimer disease: Alzheimer’sdisease (AD) is a devastating neurodegenerativedisease of increasing prevalence.1−3 The pathology of AD islinked to the self-assembly of the amyloid β (Aβ) peptideinto extracellular plaques and of the tubulin-associated unit (tau)protein into intracellular tangles in the brains of AD patients.