Recent studies have shown that GPR88 inhibits multiple GPCRs, affecting both their G protein‐ and β‐arrestin‐dependent signaling pathways.[57] Additionally, GPCRs can promote the formation of Gαi:β‐arrestin complexes that then serve as functional signaling complexes.[58] Furthermore, all components of these complexes have been revealed to be localized to cilia and to be involved in diet‐induced obesity regulation.[59, 60, 61, 62, 63, 64, 65, 66] It is difficult to distinguish the inhibition of ciliary AC3 expression from effects on other signaling pathway components. Here, ADCY3 is linked to obesity due to melanocortin 4 receptor deficiency.