HLA-E and Autoimmunity: Notably, when focusing on individual interactions of the cDCa cluster (Figure 4B), MHC class II-related transcripts (eg, CD74, HLA-E) were predicted to interact with surface molecules such as MIF or KLRC1 with immunomodulatory capacity and known association to autoimmunity (Figueiredo et al., 2018; Borrego et al., 1998).