By contrast, the present study demonstrated that Mirt2 displayed a protective role by inhibiting ox-LDL-induced macrophage migration and lipid accumulation, intracellular TC levels and lipid synthesis-associated gene expression, including Srebp1c, SCAP, FASN and PPARγ, indicating that Mirt2 may serve a critical role in cardiac diseases, including myocardial infarction and AS. The gene discussed is SREBF1; the disease is myocardial infarction.