GYS2 and intrahepatic cholangiocarcinoma: After elucidating the clinical significance of GYS2, functional studies have shown that the proliferation, migration and metastasis of ICC cells are significantly impaired when GYS2 is overexpressed, and when GYS2 is silenced, the above-mentioned capabilities are dramatically improved, which fully demonstrates the GYS2 played a role of tumor suppressor gene in the progress of ICC.