MiR‐497 and miR‐195 combine with the 3′‐UTR of Smurf2, and upregulation of miR‐497 and miR‐195 reduces lung cancer cell colonization ability and invasion by suppressing the ubiquitination of TGF‐β RI via inhibition of the target gene Smurf2.19 This evidence concerns the gene SMURF2 and lung cancer.