The results are consistent with the role of ARID1a as tumor suppressor and with genetic evidence indicating that attenuation of ARID1a levels potently fosters cell regeneration with in vivo phenotypes recapitulating those ascribed to YAP/TAZ activation, such as pancreatic acinar to ductal metaplasia, liver regeneration and cardiomyocyte proliferation [28]. This evidence concerns the gene ARID1A and neoplasm.