LEP and obesity due to melanocortin 4 receptor deficiency: Enriori P.J., Evans A.E., Sinnayah P., Jobst E.E., Tonelli-Lemos L.,Billes S.K., Glavas M.M., Grayson B.E., Perello M., Nillni E.A.,Grove K.L., Cowley M.A. Diet-induced obesity causes severe butreversible leptin resistance in arcuate melanocortin neurons.