Through the follow-up forest algorithm, the key obesity index (BMI index) is used as the dependent variable and the carrying status indicators of TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2, and NEGR1 are used as independent variables to perform factor importance analysis. Here, SH2B1 is linked to obesity due to melanocortin 4 receptor deficiency.