Through the follow-up forest algorithm, the key obesity index (BMI index) is used as the dependent variable and the carrying status indicators of TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2, and NEGR1 are used as independent variables to perform factor importance analysis. This evidence concerns the gene NEGR1 and obesity due to melanocortin 4 receptor deficiency.