Interestingly, immunosuppression with dexamethasone, a corticosteroid known to improve mortality in patients hospitalized with COVID-19 (ref. 15), was associated with global alteration of neutrophils as well as suppression of neutrophilic IFN networks and preferential depletion of COVID-19-enriched IFNactive neutrophils. Here, IFNA1 is linked to COVID-19.