All mice bearing WT MCA205 or TC1 cells had developed significant tumor masses at 14 days after transplantation, while none of the mice bearing Six1-deficient MCA205 or TC1 cells had (Figs. 2A, B and S2A, B), suggesting that Six1 deficiency could prevent subcutaneous tumor growth in immunocompetent mice. Here, SIX1 is linked to neoplasm.