TNF and neoplasm: Expression analysis by GSEA revealed that three gene sets (“hallmark” signatures) including “Interferon-g (IFN-γ) response” (Fig. 3A), “Tumor necrosis factor-a (TNF-α) signaling” (Fig. 3B), and “Inflammatory response” were upregulated in Six1−/− tumor tissues compared with WT MCA205 tumor tissues (Fig. 3C) [23].