To test whether compound C108 could abrogate the interaction between G3BP2 and LINC01554 and potentially be used to block ESCC metastasis induced by G3BP2, we first treated G3BP2-overexpressing KYSE410 cells, LINC01554-transfected KYSE30 cells with compound C108 and corresponding control cells, and then observed the G3BP2 expression and tumor cell metastatic abilities. The gene discussed is G3BP2; the disease is esophageal squamous cell carcinoma.