G3BP1 and cancer: In contrast to G3BP1, which has been reported to degrade c-Myc BART, and CTNNB1 mRNA transcripts, thereby promoting cancer cell growth, metastasis and invasion [31–33], and to sequester HIV-1 by inhibiting the translation and protein packaging of viral protein [34], only the SART3 mRNA transcript has been shown to be stabilized by G3BP2, resulting in the elevated expression of pluripotent transcription factors in breast cancer initiation [11].