G3BP2 and esophageal squamous cell carcinoma: To investigate the expression status of G3BP2 in ESCC, we first performed big data mining from Oncomine (https://www.oncomine.org) and TCGA databases (https://www.cancer.gov) Both databases indicated that G3BP2 was highly expressed in ESCC (Fig. 1A), which was further confirmed in the SYSUCC cohort at both the mRNA (Fig. 1B) and protein levels (Supplementary Fig. 1).