Pathological analysis of early tumour progression (2 week-post Dox induction) indicated that inactivation of p53 was unable to restore the amount of epithelial transformation that loss of β1 integrin imposes, arguing that the initial effects of β1 integrin function on early tumourigenesis are independent of p53 function (Fig. S4a, b). Here, TP53 is linked to neoplasm.