To further understand how p53 pathway regulate the transition from non-invasive to invasive carcinoma in the absence of β1 integrin, analysis of pre-invasive hyperplastic lesions at 2 week-post Dox induction for cell proliferation, apoptosis and cellular senescence showed that deletion of p53 restored the proliferative defect and abrogated the increased cell death exhibited by β1 integrin deficient lesions (Fig. 5e, f). Here, TP53 is linked to invasive carcinoma.