This would be in line with the cytotoxic effect of the pharmaceutical inhibition of autophagy in lymphoma cells: apilimod, an inhibitor of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) lipid kinase, an important regulator of endosome and lysosome function, showed maximal cytotoxic activity in malignant B cells23. Here, PIKFYVE is linked to lymphoma.