In CDA analysis, IGFBP-3 was determined to differentiate persons with cirrhosis from controls; decreased levels of IGFBP-3 in persons with cirrhosis have previously been described and attributed to the fact that IGFBP-3 is predominantly synthesized by hepatocytes and reportedly associated with severity of liver dysfunction47,48. The gene discussed is IGFBP3; the disease is Cirrhosis.