Subsequently, other proteins like Zinc Finger CCHC-Type Containing 3 (ZCCHC3)9 and Ras-GTPase-Activating Protein SH3-Domain-Binding Protein 1 (G3BP1)10 were identified as sensors for double-strand genome DNA of herpes simplex virus type 1 and vaccinia virus, or for DNA inducing Aicardi-Goutières syndrome, respectively, and the cGAS–STING pathway was established as the third paradigm for activating microglia in general except in neurodegenerative diseases. This evidence concerns the gene CGAS and neurodegenerative disease.