The independency of human Tau 410 and Tau 441 isoforms in activating the cGAS–STING pathway in mouse microglia could be a common mechanism across various tauopathies including Alzheimer’s disease (AD), given that different composition of 4R/3R tau isoforms recapitulate progression patterns of the corresponding human diseases independently of tau species and mouse strains49. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.