TREM2 signaling also leads to NFκB activation83 and our data revealed that deficiency of PQBP1-cGAS–STING pathway leads to 50% suppression of NFκB activation (Figs. 4 and 5), supporting the hypothesis that the PQBP1–cGAS–STING pathway induced by tau and TREM2-pathway induced by Aβ are complementary mechanisms involved in the activation of microglia and their conversion to disease-specific microglia in AD brains. Here, NFKB1 is linked to Alzheimer disease.