Interestingly, human FUS, TDP43, hnRNPA1, and hnRNPA2B1, which cause amyotrophic lateral sclerosis (ALS)75, contain multiple prolines (https://www.uniprot.org/), and mutations around which are related to the severity of disease76. The gene discussed is HNRNPA2B1; the disease is amyotrophic lateral sclerosis.