ASH1L and epilepsy: As shown in Fig. 2b and Supplementary Data 3, a significant number of downregulated (DOWN) genes by Ash1L deficiency were disease risk factors (Supplementary Fig. 1a, SFARI ASD: 130, P = 5.67e–09; Supplementary Fig. 1c, epilepsy: 69, P = 2.69e–06; Supplementary Fig. 1d, ID: 77, P = 1.78e–04, hypergeometric test).