DNAI3 and Azoospermia: In addition, we identified an additional bi-allelic variant of WDR63 in 121 non-obstructive azoospermia (NOA) male (M2: c.1075 C > T [p.Arg359*], CADD = 35) using Sanger sequencing (Fig. 1b and Table 1), indicating that variants of WDR63 might cause the severely decrease in sperm counts.