BBC3 and Alzheimer disease: In this study, we investigated whether two BH3-only proteins - Beclin1, an inducer of autophagy, and Puma, a pro-apoptotic protein, interact with each other and influence neuron death in AD.A set of experimental findings suggest that both Beclin1 and Puma binds with each other and play necessary roles in autophagy induction but are responsible for impaired autophagy flux and apoptotic death of neurons.