Mutation of N90 residue increases the binding affinity to S protein,399 indicating N90 glycosylation can protect host cells against viral infection.400 Atomistic molecular dynamics (MD) simulations show that N322 glycan binds to the core region of RBD of S protein from amino acid 369 to 378.40,400 The interaction between RBD and N322 residue of ACE2 is much stronger than that between RBD and N90 residue of ACE2. Here, ACE2 is linked to viral infectious disease.