Low nuclear MRE11 [46% (302/659)] was strongly associated with aggressive clinicopathological features including high tumour grade, high mitotic index, de-differentiation, marked pleomorphism, HER2+, oestrogen receptor (ER)- and high-risk Nottingham Prognostic Index (NPI) phenotypes (all p < 0.01). Here, ESR1 is linked to neoplasm.