ESR1 and neoplasm: In further cohort of 4904 tumours (cohort 2), low RAD50 mRNA was significantly associated with poor survival in the whole cohort (p = 0.01; Supplementary Figure 3A), ER+ cohort (p = 0.03; Supplementary Fig. 3B) but not in ER− cohort (p = 0.91; Supplementary Fig. 3C).