LaFavers KA reported that uromodulin could protect against AKI by suppressing the activity of transient receptor potential cation channel, subfamily M, member 2 (TRPM2), a multifunctional nonselective calcium ion channel, attenuating systemic oxidative stress via interfering with the RAC1/JNK/c-JUN pathway [41]. The gene discussed is MAPK8; the disease is acute kidney injury.