To investigate whether SNHG17 inhibits the effect of Trim23 on the degradation of PES1, we co-transfected SNHG17 and Trim23 expression vectors into CRC cells, and showed that Trim23 overexpression could decrease PES protein level, while SNHG17 overexpression could restore the decreased PES1 protein level caused by Trim23 overexpression (Fig. 3i). Here, PES1 is linked to colorectal carcinoma.