NFYA and posterior cortical atrophy: In order to identify whether the NF-YA splicing signature could correlate with PCa aggressiveness and metastatic potential, we surveyed genes highly expressed in localized vs benign and metastatic vs localized human tumors data sets [38] and checked for concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap (RRHO) approach [39].