CD4 and neoplasm: The 7 types of tumor-infiltrating lymphocytes that exhibited important correlations with SRMS in COAD included activated CD4+ T cells (Act CD4; Spearman: r = − 0.196, p = 2.37e− 05), CD56 dim natural killer cells (CD56 dim, Spearman: r = 0.283, p = 7.68e− 10), memory B cells (MEM B, Spearman: r = − 0.115, p = 0.0137), neutrophils (neutrophil, Spearman: r = 0.102, p = 0.0293), effector memory CD4+ T cells (Tem CD4, Spearman: r = − 0.296, p = 1.17e− 10), type 2 T helper cells (Th2, Spearman: r = − 0.187, p = 5.98e− 05), and type 17 T helper cell (Th17, Spearman: r = 0.23, p = 6.6e− 07).