Studies on clinical application of sorafenib in CRC patients have been conducted in recent decades [51, 52], and our findings have validated that sorafenib attenuates STOML2-induced CRC proliferation and tumor growth, with antagonizing effect to MAPK pathway (Fig. 6A), which may provide evidence for potential use of sorafenib in decreasing tumor burden of CRC. This evidence concerns the gene STOML2 and colorectal carcinoma.