We picked top 20 pathway terms with highest normalized enrichment score (NES) of each gene; as is shown, overexpressed STOML2 was correlated with upregulation in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways like “RNA polymerase”, “pyrimidine metabolism”, “cell cycle”, “DNA replication”, indicating its functional connection with proliferation in CRC (Supplementary Fig.3A). Here, STOML2 is linked to colorectal carcinoma.