JP Roperch, etl firstly reports Presenilin1 is downregulated in a series of model systems for p53-dependent and p53-independent apoptosis and tumor suppression, and down-expression of Presenilin1 results in reduced growth with increased apoptosis in U937 cells, suggesting Presenilin1 acts as promotor in tumorigenesis [28]. Here, TP53 is linked to neoplasm.