CDH1 and central nervous system cancer: On the other hand, The Presenilin1/gamma-secretase system stimulates disassembly of the E-cadherin-catenin complex to release the cytoplasmic E-cadherin to the cytosol and increases the levels of solubleβ- and α-catenin [15, 37].Recently, it is generally acknowledged that the source of glioma cell was not from epithelial cells.