EZH2 and triple-A syndrome: Using RT-qPCR and Western blot analysis, we found an increase in RIG-I expression in AAA mice compared with the controls while it was downregulated in oe-EZH2-treated AAA mice comparted with oe-NC-treated AAA mice (p < 0.05) (Fig. 3A, B), suggesting EZH2 can inhibit RIG-I expression in AAA mice.