The treatment of lung adenocarcinoma has evolved considerably due to the emergence of specifically targeted therapies against identified molecular drivers, such as epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), and murine sarcoma viral oncogene homolog B (BRAF). This evidence concerns the gene EGFR and lung adenocarcinoma.