The down-regulated p-DNA-PK and Rad51 in A498/R with shPDIA6 transfection was up-regulated by the over-expression of FZD1 (Figure 6(c)), indicating that PDIA6 contributed to the imatinib-resistance of renal cell carcinoma through activation of Wnt3a-FZD1 pathway. The gene discussed is PRKDC; the disease is hereditary clear cell renal cell carcinoma.