MICB and colon carcinoma: It has also been found that overexpression of the EBV microRNA (miRNA) MiR-BART2-5p reduced expression of the NKG2D ligand MICB in RKO colon carcinoma cells, and a sponge directed against this miRNA led to an increase in MICB levels in the EBV-positive LCL 721, rendering these cells more susceptible to NK cell-mediated killing (23).