HDGFL2 and malaria: Currently available malaria RDTs use several key biomarkers to differentiate between species: P. falciparum-specific histidine-rich protein 2 (HRP2) or/and lactate dehydrogenase (PfLDH) for P. falciparum, and P. vivax-specific lactate dehydrogenase (PvLDH) for P. vivax.