MTAP is deletedin around 15% of cancers, and therefore, Mat2A inhibitors are attractivecandidates for targeting cancers with MTAP deletion.24,25 Several potent inhibitors of Mat2A have recently been described(PF-9366, AG-270, compound 28).10,24,26 Interestingly, these inhibitors bind to the same site as Mat2B.10,26,27 AG-270 and compound 28 have beenshown to inhibit cancer cell growth and proliferation of MTAP-deficientcancer cells and tumors. The gene discussed is MAT2B; the disease is cancer.