In contrast, both high expression groups of SLC2A1 (rs710218; TT, rs841851; AA) showed a significant APOE4-associated risk of developing cognitive decline (rs710218: p = 0.037, OR = 2.35, 95% CI, 1.05–5.23, rs841851: p = 0.0012, OR = 3.2, 95% CI, 1.58–6.46), whereas none of the low expression groups (rs710218: TA+AA, rs841851: AG+GG) showed a significant APOE4-associated risk of developing cognitive decline (rs710218: p = 0.49, OR = 1.3 and 95% CI, 0.62–2.75, rs841851: p = 0.39, OR = 0.67, 95% CI, 0.27–1.67) (Table 2). The gene discussed is SLC2A1; the disease is Mental deterioration.