The multivariate logistic regression analysis adjusted for the effects of age, follow-up period, education period, MMSE points at baseline, frequencies of hypertension and hyperlipidemia, standardized VC levels, and sex showed that APOE4 is an independent risk factor for cognitive decline (MCI or dementia) (S1 Table: p = 0.027, OR = 1.91, and 95% CI, 1.10–3.33). Here, APOE is linked to hypertensive disorder.